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KMID : 0605720100160020156
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Journal of the Korean Society of Biological Therapies in Psychiatry
2010 Volume.16 No. 2 p.156 ~ p.166
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A Comparison of Memory in Early Alzheimer’s Disease and Major Depressive Disorder
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Lee Ji-Soung
Bae Geum-Ye
Lee Jung-Jae
Kim Ki-Woong
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Abstract
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Objectives: We aimed to evaluate the memory function of early Alzheimer’s disease(AD) group and Major depressive disorder(MDD) group compared with normal control(NC) group and to investigate the accuracy of memory function in differentiation of each group.
Methods: Fifty early AD patients and 30 MDD patients and 30 age- and sex- and education-matched NC subjects were selected. The Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease assessment packet(CERAD-K), Logical Memory Test(LMT), and Benton Visual Retention Test(BVRT) were administered.
Results: Early AD group performed significantly worse than MDD and NC group in most verbal and visual memory tests. In contrast, MDD group obtained more impaired score than NC in most tests but no significantly differences were found between MDD and NC except for delayed recall test of verbal memory. Discrimination analysis of quantitative indices demonstrated 86.3% of diagnosis precision rate. Also discrimination analysis of qualitative indices which measured the process of memory indicated that overall percentage correct classification was 93.8%.
Conclusion: In quantitative indices, constructional recall test(CRT) and word list recall(WLR) were highly correlated with function which discriminates between early AD and MDD group. In qualitative indices, learning slope of LMT, false positive error and intrusion error of CERAD-K, distortion error of BVRT, and response time of BVRT have high discriminating power.
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KEYWORD
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Early Alzheimer’s disease, Major depressive disorder, Memory
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